Aug 5, 2021
This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent key opportunity areas, enabling broad deployment in the context of field studies, clinical trials, and recent commercialization. On-body measurements in these contexts show good agreement compared to conventional laboratory-based sweat analysis approaches. These device demonstrations highlight the utility of biochemical sensing platforms for personalized assessment of performance, wellness, and health across a broad range of applications.
Mar 31, 2021
Science Translational Medicine
This month's cover feature of Science Translational Medicine highlights research done in partnership with Epicore and Northwestern University teams to improve diagnosis and management for cystic fibrosis. Here, we introduce a soft, epidermal microfluidic device (“sweat sticker”) designed for the simple and rapid collection and analysis of sweat. Intimate, conformal coupling with the skin supports nearly perfect efficiency in sweat collection without leakage. Real-time image analysis of chloride reagents allows for quantitative assessment of chloride concentrations using a smartphone camera, without requiring extraction of sweat or external analysis. Clinical validation studies involving patients with CF and healthy subjects, across a spectrum of age groups, support clinical equivalence compared to existing device platforms in terms of accuracy and demonstrate meaningful reductions in rates of leakage. The wearable microfluidic technologies and smartphone-based analytics reported here establish the foundation for diagnosis of CF outside of clinical settings.
Dec 11, 2020
Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications
Here, we introduce a skin-interfaced wearable microfluidic device and smartphone image processing platform that enable analysis of regional sweating rate and sweat chloride concentration ([Cl−]). Systematic studies (n = 312 athletes) establish significant correlations for regional sweating rate and sweat [Cl−] in a controlled environment and during competitive sports under varying environmental conditions.
Nov 10, 2020
Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities
Skin-interfaced, wireless devices for clinical-grade monitoring of physiological parameters are of growing interest for uses that range from healthcare to sports performance. This paper, by researchers at Epicore Biosystems and Northwestern University, introduces a multifunctional skin-mounted microfluidic platform for capture and biomarker analysis of microliter volumes of sweat, a biofluid that can be collected noninvasively, with potential relevance in biophysical sensing.
Jul 13, 2020
Epicore Biosystems and Northwestern University report a biocompatible, sweat-activated battery technology that can be embedded within a soft, microfluidic platform. The battery can be used in a detachable electronic module that contains wireless communication and power management systems, and is capable of continuous on-skin recording of physiological signals. To illustrate the practical utility of our approach, we show, using human trials, that the sweat-activated batteries can operate hybrid microfluidic/ microelectronic systems that simultaneously monitor heart rate, sweat chloride and sweat pH.
Jun 16, 2020
Rapid Capture and Extraction of Sweat for Regional Rate and Cytokine Composition Analysis Using a Wearable Soft Microfluidic System
Journal of Investigative Dermatology
This Letter to the Editor highlights a study employing Epicore Biosystems's Discovery patch, a soft, skin-interfaced microfluidic patch in development, to enable rapid capture and extraction of sweat volumes for the analysis of cytokines. This initial study highlighted in JID was completed in June 2019 in collaboration with Northwestern University dermatologists to establish baseline data using the Discovery platform and to test its clinical utility. Patches were skin mounted on 10 healthy individuals to collect sweat when individuals were exposed to heat in a controlled environment. Concentrations of three cytokines – IL-1α, IL-1RA, and IL-8 – were assessed twice a day and on consecutive days. The team demonstrated the ability to quantify the concentrations of target inflammation biomarkers in sweat across different skin locations.
Feb 12, 2020
Wearable sensors might soon provide dermatologists and patients with unprecedented real-time information about skin health. One such device in development, Epicore Biosystems’ wearable Discovery patch (Leo Pharma and Epicore Biosystems), aims to assess inflammatory biomarkers found in sweat and interstitial fluid in individuals with atopic dermatitis. The wearable technology will analyze cytokines in sweat to offer real-time objective assessment of the state of disease in adults with the chronic skin condition.
BMC Biomedical Engineering
Here we examine the feasibility of utilizing an advanced wearable sensor, fabricated with stretchable electronics, to characterize linear and angular movements of the human arm for clinical feedback.
Role of data measurement characteristics in the accurate detection of Parkinson’s disease symptoms using wearable sensors
Journal of NeuroEngineering and Rehabilitation
Parkinson’s disease (PD) is a progressive neurological disease, with characteristic motor symptoms such as tremor and bradykinesia. There is a growing interest to continuously monitor these and other symptoms through body-worn sensor technology. However, limited battery life and memory capacity hinder the potential for continuous, long-term monitoring with these devices. Here we build on a previous study to investigate the relationship between data measurement characteristics and accuracy when using wearable sensor data to classify tremor and bradykinesia in patients with PD.
Soft, skin-interfaced sweat stickers for cystic fibrosis diagnosis and management Science Translational Medicine (2021)
Rapid Capture and Extraction of Sweat for Regional Rate and Cytokine Composition Analysis Using a Wearable Soft Microfluidic System Journal of Investigative Dermatology (2021)
Sweat-activated biocompatible batteries for epidermal electronic and microfluidic systems Nature Electronics (2020)
Can mHealth Technology Help Mitigate the Effects of the COVID-19 Pandemic? IEEE Open Journal of Engineering in Medicine and Biology (2020)
Don’t Sweat It: The Quest for Wearable Stress Sensors Matter (2020)
Wearable Sensors for Biochemical Sweat Analysis Annual Review of Analytical Chemistry (2019)
Counting Bites With Bits: Expert Workshop Addressing Calorie and Macronutrient Intake Monitoring Journal of Medical Internet Research (2019)
Soft, skin-interfaced wearable systems for sports science and analytics Current Opinion in Biomedical Engineering (2019)
Bio-Integrated Wearable Systems: A Comprehensive Review American Chemical Society (2019)
Skin-interfaced systems for sweat collection and analytics Science Advances (2018)
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat Science Translational Medicine (2016)